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	Provedor de dados BJMBR (2) Autor Abdalla,D.S.P. (2) Ajzen,S. (1) Ferderbar,S. (1) Grosso,D.M. (1) Higushi,M.L. (1) Krieger,M.H. (1) Moriel,P. (1) Plavnik,F.L. (1) Rubbo,H. (1) Sevanian,A. (1) Wanschel,A.C.B.A. (1) Zanella,M.T. (1) Mais... Palavra-chave Atherogenesis (1) Endothelin-1 (1) Lipid peroxidation (1) Minimally modified LDL (1) Monoclonal antibody (1) Nitrate (1) Nitrotyrosine (1) Oxidized LDL (1) Passive immunization (1) S-nitrosothiols (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2008 (1) 2002 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antibodies against electronegative LDL inhibit atherosclerosis in LDLr-/- mice BJMBR Grosso,D.M.; Ferderbar,S.; Wanschel,A.C.B.A.; Krieger,M.H.; Higushi,M.L.; Abdalla,D.S.P.. In order to determine the effect of antibodies against electronegative low-density lipoprotein LDL(-) on atherogenesis, five groups of LDL low receptor-deficient (LDLr-/-) mice (6 per group) were immunized with the following antibodies (100 µg each): mouse anti-LDL(-) monoclonal IgG2b, rabbit anti-LDL(-) polyclonal IgG or its Fab fragments and mouse irrelevant monoclonal IgG and non-immunized controls. Antibodies were administered intravenously one week before starting the hypercholesterolemic diet (1.25% cholesterol) and then every week for 21 days. The passive immunization with anti-LDL(-) monoclonal IgG2b, polyclonal antibody and its derived Fab significantly reduced the cross-sectional area of atherosclerotic lesions at the aortic root of LDLr-/- mice... Tipo: Info:eu-repo/semantics/article Palavras-chave: Minimally modified LDL; Passive immunization; Monoclonal antibody; Atherogenesis. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200007 Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension BJMBR Moriel,P.; Sevanian,A.; Ajzen,S.; Zanella,M.T.; Plavnik,F.L.; Rubbo,H.; Abdalla,D.S.P.. The objective of the present study was to identify disturbances of nitric oxide radical (·NO) metabolism and the formation of cholesterol oxidation products in human essential hypertension. The concentrations of·NO derivatives (nitrite, nitrate, S-nitrosothiols and nitrotyrosine), water and lipid-soluble antioxidants and cholesterol oxides were measured in plasma of 11 patients with mild essential hypertension (H: 57.8 ± 9.7 years; blood pressure, 148.3 ± 24.8/90.8 ± 10.2 mmHg) and in 11 healthy subjects (N: 48.4 ± 7.0 years; blood pressure, 119.4 ± 9.4/75.0 ± 8.0 mmHg).Nitrite, nitrate and S-nitrosothiols were measured by chemiluminescence and nitrotyrosine was determined by ELISA. Antioxidants were determined by reverse-phase HPLC and cholesterol oxides... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitrotyrosine; S-nitrosothiols; Nitrate; Oxidized LDL; Lipid peroxidation; Endothelin-1. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100007 Registros recuperados: 2 Primeira ... 1 ... Última

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